PixabayâTriclosanâs increasingly broad use in consumer products presents a risk of liver toxicity for humans,â said Robert H. Tukey, PhD, professor in the Department of Pharmacology at UC San Diego School of Medicine. ÂOur study shows that common factors that we encounter in every-day life â the ubiquitous presence of triclosan, together with the prevalence of high consumption of dietary fat âconstitute a good recipe for the development of fatty liver disease in mice.âTukey led the study with Mei-Fei Yueh, PhD, a project scientist in his lab, and Michael Karin, PhD, Distinguished Professor of Pharmacology and Pathology at UC San Diego School of Medicine.In a 2014 mouse study, the team found triclosan exposure promoted liver tumor formation by interfering with a protein responsible for clearing away foreign chemicals in the body.
In the latest study, the researchers fed a high-fat diet to mice with type 1 diabetes. As previous studies have shown, the high-fat diet led to non-alcoholic fatty liver disease (NAFLD). In humans, NAFLD is an increasingly common condition that can lead to liver cirrhosis and cancer.
Diabetes and obesity are risk factors for NAFLD. Some of the mice were also fed triclosan, resulting in blood concentrations comparable to those found in human studies. Compared to mice only fed a high-fat diet, triclosan accelerated the development of fatty liver and fibrosis.
According to the study, hereâs whatâs likely happening. Eating a high-fat diet normally tells cells to produce more fibroblast growth factor 21, which helps protects liver cells from damage. Tukey and team discovered that triclosan messes with two molecules, ATF4 and PPARgamma, which cells need to make the protective growth factor.
Not only that, the antimicrobial also disrupted a variety of genes involved in metabolism. In addition, the mice exposed to triclosan had less diversity in their gut microbiomes â fewer types of bacteria living in the intestines, and a makeup similar to that seen in patients with NAFLD. Less gut microbiome diversity is generally associated with poorer health.So far, these findings have only been observed in mice who ingested triclosan.
But since these same molecular systems also operate in humans, the new information will help researchers better understand risk factors for NAFLD, and give them a new place to start in designing potential interventions to prevent and mitigate the condition. ÂThis underlying mechanism now gives us a basis on which to develop potential therapies for toxicant-associated NAFLD,â said Tukey, who is also director of the National Institute of Environmental Health Sciences Superfund Program at UC San Diego.In 2016, the U.S. Food and Drug Administration (FDA) ruled that over-the-counter wash products can no longer contain triclosan, given that it has not been proven to be safe or more effective than washing with plain soap and water.
However, the antimicrobial is still found in some household and medical-grade products, as well as aquatic ecosystems, including sources of drinking water.An estimated 100 million adults and children in the U.S. May have NAFLD. The precise cause of NAFLD is unknown, but diet and genetics play substantial roles.
Up to 50 percent of people with obesity are believed to have NAFLD. The condition typically isnât detected until itâs well advanced. There are no FDA-approved treatments for NAFLD, though several medications are being developed.
Eating a healthy diet, exercising and losing weight can help patients with NAFLD improve.Additional co-authors of the study include. Feng He, Chen Chen, Catherine Vu, Anupriya Tripathi, Rob Knight, and Shujuan Chen, all at UC San Diego.Funding for this research came, in part, from the National Institutes of Health (grants ES010337, R21-AI135677, GM126074, CA211794, CA198103, DK120714), Eli Lilly and UC San Diego Center for Microbiome Innovation. Disclosure.
Michael Karin is a founder, inventor and an Advisory Board Member of Elgia Therapeutics and has equity in the company.Women using a common, injectable form of birth control showed increased levels of potentially hazardous lead in their blood, a study led by a Michigan State University researcher found. The study reported that women who were currently using the contraceptive depot medroxyprogesterone acetate, or DMPA, had 18% higher levels of lead in their blood on average than those who were not using it. Kristen Upson, an assistant professor of epidemiology and biostatistics in MSU College of Human Medicine and lead author of the study, said she suspected DMPA, sold under the brand name Depo-Provera, could be associated with higher levels of blood lead because of its effect on bone.
A known possible side effect is loss of bone mineral density during its use. With bone loss there can be a release of lead that is stored in bone. About 90% of lead that enters the body is stored in the bones.
ÂWe do not know how 18% translates to adverse health effects. What we do know is that the widespread scientific consensus is that there is no safe blood lead level,â Upson said. The study, published in the journal Environmental Health Perspectives, included 1,548 African American women participating in research to learn more about the development of uterine fibroids, a condition that disproportionately affects African American women.
The project was initiated and data is collected through the Detroit Study of Environment, Lifestyle, and Fibroids, sponsored by the National Institute of Environmental Health Sciences, part of the National Institutes of Health. Upson said that since current DMPA users and those not using DMPA were compared at one time point, it is possible that other differences between current users and nonusers could explain the result. ÂHowever, our finding persisted even after conducting additional analyses to account as best we could for these differences,â Upson said.
The U.S. Food and Drug Administration approved DMPA for birth control in 1992, and one in five sexually active women in the United States have used it. A single injection provides three months of contraceptive coverage to prevent pregnancy.
Worldwide, some 74 million women use injectable contraception. ÂWhile lead exposure in children commonly is associated with neurodevelopmental problems, it can affect all organ systems even in adulthood,â Upson said. ÂThatâs why itâs so important to do further research.â The latest findings do not suggest that DMPA should be banned.
ÂIt is such an important form of contraception that we really need to do more research to make sure that other studies confirm this finding,â she said. Upson said she hopes to conduct further research following women from when they start using DMPA until after they stop using it to further assess the drugâs potentially adverse health effects. Data collection for this investigation was funded by NIEHS, NIH, and from funds allocated for health research by the American Recovery and Reinvestment Act.
Additional support came from the National Institute of Nursing Research and the Office of Disease Prevention. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. (Note for media.
Please include a link to the original paper in online coverage. https://doi.org/10.1289/EHP7017).
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A new study reported Bonuses Saturday cialis ou viagra ou levitra forum at the virtual European Congress on Obesity (ECO) found that people on vegetarian diets have lower blood levels of disease-linked biomarkers, such as "bad" (LDL) cholesterol and other factors. Biomarkers can have harmful and beneficial health impacts, promoting or preventing cancer, heart and age-related diseases and other chronic conditions. And while they've long been used to assess the effect of diets on health, it hasn't been clear how being vegetarian affects biomarkers. To find out, the researchers analyzed data from nearly 178,000 British people, cialis ou viagra ou levitra forum aged 37 to 73.
The study participants reported no major diet changes in the previous five years. They were categorized as either vegetarian (do not eat red meat, pouy or fish) or meat eaters. The investigators then examined the association between diet and 19 blood and urine biomarkers related cialis ou viagra ou levitra forum to diabetes, cardiovascular diseases, cancer, liver, bone and joint health, and kidney function. After accounting for other factors â such as age, sex, obesity, smoking and alcohol use â the researchers found that vegetarians had significantly lower levels of 13 biomarkers than meat eaters.
Those biomarkers included. Total cholesterol cialis ou viagra ou levitra forum. LDL cholesterol. Apolipoprotein A and apolipoprotein B (linked to heart disease).
Gamma-glutamyl transferase and cialis ou viagra ou levitra forum alanine aminotransferase (which are liver function markers indicating inflammation or damage to cells). Insulin-like growth factor (a hormone that encourages the growth and proliferation of cancer cells). Urate (tied to gout). And creatinine (a marker cialis ou viagra ou levitra forum of worsening kidney function).
"Our findings offer real food for thought," study leader Carlos Celis-Morales, of the University of Glasgow, in Scotland, said in an ECO news release. "As well as not eating red and processed meat, which have been linked to heart diseases and some cancers, people who follow a vegetarian diet tend to consume more vegetables, fruits and nuts, which contain more nutrients, fiber and other potentially beneficial compounds," he said. "These nutritional differences may help explain why vegetarians appear to have lower levels of disease biomarkers that can look at here now lead to cell damage and chronic disease." It wasn't all good news for cialis ou viagra ou levitra forum vegetarians, however. The study found that they tended to have lower levels of beneficial biomarkers, including "good" (HDL) cholesterol, and vitamin D and calcium (linked to bone and joint health), as well as significantly higher levels of fats in the blood (triglycerides) and cystatin-C (suggesting poorer kidney health).
And no matter whether people ate meat or not, the study found no link between diet and blood sugar levels, systolic blood pressure (the top number in a reading), aspartate aminotransferase (a marker of damage to liver cells) or C-reactive protein (an inflammatory marker). SLIDESHOW Diet-Wrecking cialis ou viagra ou levitra forum Foods. Smoothies, Lattes, Popcorn, and More in Pictures See Slideshow Nevertheless, plant-based diets are largely considered to be healthier, one U.S.-based nutritionist said. "I encourage my patients to base their diet on whole plant foods," said Christine Santori, who manages the clinical dietary program at the Center for Weight Management at Northwell Health's Syosset Hospital in Syosset, N.Y.
"Consuming fruit, vegetables, whole grains, legumes, nuts and seeds cialis ou viagra ou levitra forum as the base of the diet provides beneficial fiber with little saturated fat," she noted. "If they choose to consume animal products, I encourage them to stick to fish and skinless pouy and consider it a side dish." But eschewing meat leaves a wide variety of diets. Vegan, vegetarian, pescatarian (fish but no meat), lacto-ovo (no meat but eggs and dairy allowed), and "flexitarian" (where folks still occasionally have meat). And some vegetarians can still cialis ou viagra ou levitra forum be unhealthy, Santori noted.
"I have seen 'vegetarians' who consume mostly refined carbohydrates and highly processed foods, who are not very healthy," she said. Still, "the truth is that consuming more fruits and vegetables can boost your health whether you define yourself as a vegetarian or not," Santori said. "It may be more about what vegetarians are eating as opposed to it being about what they are not." Because the new findings were presented at cialis ou viagra ou levitra forum a medical meeting, they should be considered preliminary until published in a peer-reviewed journal. More information The U.S.
National Institutes of Health has more on healthy eating. SOURCES. Christine Santori, RDN, manager, clinical dietary program, Center for Weight Management, Northwell Health's Syosset Hospital, Syosset, N.Y.. European Congress on Obesity, news release, May 8, 2021 Copyright © 2021 HealthDay.
A new study reported Saturday at the virtual European levitra pill price Congress on Obesity (ECO) found site here that people on vegetarian diets have lower blood levels of disease-linked biomarkers, such as "bad" (LDL) cholesterol and other factors. Biomarkers can have harmful and beneficial health impacts, promoting or preventing cancer, heart and age-related diseases and other chronic conditions. And while they've long been used to assess the effect of diets on health, it hasn't been clear how being vegetarian affects biomarkers.
To find levitra pill price out, the researchers analyzed data from nearly 178,000 British people, aged 37 to 73. The study participants reported no major diet changes in the previous five years. They were categorized as either vegetarian (do not eat red meat, pouy or fish) or meat eaters.
The investigators then examined the association between diet levitra pill price and 19 blood and urine biomarkers related to diabetes, cardiovascular diseases, cancer, liver, bone and joint health, and kidney function. After accounting for other factors â such as age, sex, obesity, smoking and alcohol use â the researchers found that vegetarians had significantly lower levels of 13 biomarkers than meat eaters. Those biomarkers included.
Total cholesterol levitra pill price. LDL cholesterol. Apolipoprotein A and apolipoprotein B (linked to heart disease).
Gamma-glutamyl transferase and alanine aminotransferase (which are liver function markers indicating levitra pill price inflammation or damage to cells). Insulin-like growth factor (a hormone that encourages the growth and proliferation of cancer cells). Urate (tied to gout).
And creatinine (a levitra pill price marker of worsening kidney function). "Our findings offer real food for thought," study leader Carlos Celis-Morales, of the University of Glasgow, in Scotland, said in an ECO news release. "As well as not eating red and processed meat, which have been linked to heart diseases and some cancers, people who follow a vegetarian diet tend to consume more vegetables, fruits and nuts, which contain more nutrients, fiber and other potentially beneficial compounds," he said.
"These nutritional differences may help explain why vegetarians http://harringtonlearning.com/wpcf7_contact_form/contact-form-1/ appear to have levitra pill price lower levels of disease biomarkers that can lead to cell damage and chronic disease." It wasn't all good news for vegetarians, however. The study found that they tended to have lower levels of beneficial biomarkers, including "good" (HDL) cholesterol, and vitamin D and calcium (linked to bone and joint health), as well as significantly higher levels of fats in the blood (triglycerides) and cystatin-C (suggesting poorer kidney health). And no matter whether people ate meat or not, the study found no link between diet and blood sugar levels, systolic blood pressure (the top number in a reading), aspartate aminotransferase (a marker of damage to liver cells) or C-reactive protein (an inflammatory marker).
SLIDESHOW Diet-Wrecking Foods levitra pill price. Smoothies, Lattes, Popcorn, and More in Pictures See Slideshow Nevertheless, plant-based diets are largely considered to be healthier, one U.S.-based nutritionist said. "I encourage my patients to base their diet on whole plant foods," said Christine Santori, who manages the clinical dietary program at the Center for Weight Management at Northwell Health's Syosset Hospital in Syosset, N.Y.
"Consuming fruit, vegetables, whole grains, legumes, nuts and seeds as the base of the diet levitra pill price provides beneficial fiber with little saturated fat," she noted. "If they choose to consume animal products, I encourage them to stick to fish and skinless pouy and consider it a side dish." But eschewing meat leaves a wide variety of diets. Vegan, vegetarian, pescatarian (fish but no meat), lacto-ovo (no meat but eggs and dairy allowed), and "flexitarian" (where folks still occasionally have meat).
And some vegetarians can still be unhealthy, Santori levitra pill price noted. "I have seen 'vegetarians' who consume mostly refined carbohydrates and highly processed foods, who are not very healthy," she said. Still, "the truth is that consuming more fruits and vegetables can boost your health whether you define yourself as a vegetarian or not," Santori said.
"It may be more about what vegetarians are eating as opposed to it being about what they are not." Because the new findings were presented at a medical meeting, levitra pill price they should be considered preliminary until published in a peer-reviewed journal. More information The U.S. National Institutes of Health has more on healthy eating.
SOURCES. Christine Santori, RDN, manager, clinical dietary program, Center for Weight Management, Northwell Health's Syosset Hospital, Syosset, N.Y.. European Congress on Obesity, news release, May 8, 2021 Copyright © 2021 HealthDay.
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